The Relation of Mind and Body as Understood by Interactions of the Immune System and the Brain

The Secret Language of Cells describes revolutionary findings about the interaction of the immune system and the brain and provides a new understanding of the relationship between mind and body.

The immune system has a huge impact on the brain and mental health. Similarly, the brain strongly influences immune activity throughout the body. These interactions profoundly affect general cognition and memory and are highly related to depression, anxiety, pain, and the responses to stress, as well as inflammation and other immune and brain diseases.

In fact, the definition of brain must be expanded from the wired set of neuronal circuits to include the vast wireless system consisting of traveling immune cells, as well as many other types of cells, which are in constant communication with local neurons and the brain as a whole.

Likewise, if the mind is considered to be either determined by the brain, or related to activity of the brain, then the definition of mind must be expanded to include the constant communication of all cells throughout the body not just in the central nervous system. This ubiquitous signaling among all cells in the body and the brain, using large communication circuits, is a strong indication that there really is only one interactive system encompassing body, brain, and mind. This is, perhaps, most exemplified in recent research by vital two way interactions of the immune system and the brain.

Back and forth conversations between travelling immune cells and stationary brain cells use signals consisting of molecules, and molecule-filled sacs, that are secreted into tissues, blood vessels, and cerebrospinal fluid (CSF). Neuronal signals to immune cells in tissues throughout the body are sent not only from synapses, as has been the traditional understanding, but also from regions along the axons where there is no myelin. T cells—the master immune regulator cells—not only send local signals to nearby nerves in tissues, but also send signals to the brain while traveling in the CSF. These signals are relayed to specific regions of the brain by cells that line the chambers that hold the CSF.

Important examples of the impact of two-way communication between the immune system and the brain include:

  • DEPRESSION: Signals from T cells can alter the production of new brain cells in the hippocampus memory center, and therefore, increase or decrease memory ability. In people who are depressed, T cells send signals that cause a decrease in production of new brain cells, which correlates with reduced memory, and they send signals to increase inflammation. When depression is treated, the T cells start sending signals to stimulate production of new neurons, better memory, and decreased inflammation.


  • STRESS AND ANXIETY: Short term stress can be beneficial since it triggers T cells to send signals that increase productions of neurons in the memory and learning centers. However, with long term stress, T cell signals produce damaging inflammation and decreased production of memory cells.


  • SICK FEELING: When we are ill with a fever, our T cells, aware of the infection, send a signal through the CSF for the brain to slow down and change our awareness to that of the “sick feeling.” The feeling of being ill triggered by these signals makes us take care of ourselves and rest. Once health is restored, T cells send continuous pulses of signals to maintain ordinary cognition.


  • ACUPUNCTURE: Signaling between T cells and neurons provides an explanation for acupuncture having broad effects on pain in bodily regions far from the acupuncture point. Stimulating the acupuncture point triggers a local T cell to send a signal into the tissue that travels to a nearby neuron. The neuron then relays the signal to the brain circuits, which then communicate with distant areas of the body to cause the acupuncture effect.


  • PAIN: Newly discovered large complex synapses and circuits have been found in conjunction with chronic pain syndromes. These unusual pain-related synapses provide a connection between more types of cells than have previously been observed—one synapse or circuit can include multiple neurons, supportive brain cells, multiple immune cells, organ lining cells, and even microbes. Learning more about these synapses, circuits, and signals will enable the development of new types of treatments for chronic pain syndromes.


  • INFLAMMATION: Neuronal signals throughout the body work in tandem with immune cells during the response to infections, cancer, and trauma to produce an inflammatory response. In fact, neuron signals can produce all four primary symptoms of inflammation—redness, heat, swelling, and pain in any region.


Continued investigation into the signals between immune cells and brain cells will lead to new types of treatments for depression, anxiety, stress, pain, inflammation, and other immune and brain diseases.

There is much more about the immune-brain interactions, and the full body brain interactions, in theThe Secret Language of Cells new book, The Secret Language of Cells.


The Secret Language of Cells… will fascinate those interested in new frontiers of neuroscience.”

Publisher’s Weekly


The Secret Language of Cells … presents a new paradigm for understanding health and disease. It also suggests new possibilities for treatment and for promoting healing.”

Andrew Weil, MD, director of the Andrew Weil Center for Integrative Medicine, professor at University of Arizona College of Medicine, and author


“… a must read for anyone seeking to understand modern biology and advanced medical science.”

Ray Kurzweil, inventor, author, and futurist


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